"Haemosiderin staining" describes orange/red/brown skin hyperpigmentation caused by haemosiderin (an iron-containing pigment found in blood) leaking into the skin.
Causes:
Chronic venous insufficiency (in lower legs)
Skin inflammation
Trauma e.g. wound, fracture, surgery
Pigmented purpuric dermatoses
Haemochromatosis
Haemosiderin staining may be exacerbated by anticoagulant use as this increases extravasation (leakage) of red blood cells into the skin.
See an example here.
The renin-angiotensin system that helps regulate the constriction of blood vessels and blood pressure.
I don’t know what stage of the semester you’re at right now but let someone in exam period (me) give you some advice on revision: Start early. Early as in NOW. Start now to not end up like me
In the UK and US, the main causes are gallstones and alcohol.
Use the mnemonic 'I GET SMASHED':
Idiopathic
Gallstones
Ethanol
Trauma
Steroids
Mumps / Malignancy
Autoimmune
Scorpion stings
Hypercalcaemia / Hypertriglyceridaemia / Hypothermia
ERCP
Drugs (including azathioprine, mesalazine, bendroflumethiazide, furosemide, steroids, sodium valproate)
ACh acts on N2 receptors (ligand-gated Na+/K+ receptors)
Block Na+ channels that propagate nerve impulse - local anaesthetics (lidocaine), tetrodotoxin
Inhibit ACh release - tetanus toxin, botulinum toxin
Competitive antagonists - vecuronium
N2 agonists - suxamethonium
Flaccid paralysis
Only cleared by plasma cholinesterase
Reversible anticholinesterases - edrophonium, neostigmine, physostigmine
Block activity of AChE
Diagnose and treat myasthenia gravis and treat glaucoma respectively
Irreversible anticholinesterases - organophosphates (pesticides, nerve gases)
Long-lived flaccid paralysis
Treat with pralidoxime within 10 minutes - cleaves OP-AChE complex
So Long Till Pinky, Here Comes The Thumb
Scaphoid
Lunate
Triquetrum
Pisiform
Hamate
Capitate
Trapezoid
Trapezium
(going anti-clockwise in this diagram)
Morphine (+ anti-emetic)
Oxygen
Nitrate
Anti-platelet (aspirin, clopidogrel)
Thrombolytic (rtPA)
Primary angioplasty (PTCA)
Anticoagulant (heparin)
Beta-blocker
ACE inhibitor
Aspirin
Lipid-lowering (statin)
Lifestyle
Helpful mnemonic foe MI treatment.
Furosemide (and other loop diuretics) Aminoglycosides Vancomycin Quinine Aspirin
On, on, on, they travelled and found Voldemort guarding very ancient horcruxes.
Olfactory, optic, oculomotor, trochlear, trigeminal, abducens, facial, vestibulocochlear, glossopharyngeal, vagus, accessory, hypoglossal.
On - Olfactory nerve (CN I)
On - Optic nerve (CN II)
On - Oculomotor nerve (CN III)
They - Trochlear nerve (CN IV)
Travelled - Trigeminal nerve (CN V)
And - Abducens nerve (CN VI)
Found - Facial nerve (CN VII)
Voldermort - Vestibulocochlear nerve (CN VIII)
Guarding - Glossopharyngeal nerve (CN IX)
Very - Vagus nerve (CN X)
Ancient - Accessory nerve (CN XI)
Horcruxes - Hypoglossal nerve (CN XII)
Alternatively:
Some Say Money Matters But My Brother Says Big Brains Matter More
Sooo… while studying the cranial nerves and their functions I came by this genius mnemonic and I just had to share it with you guys! :D
Some say money matters, but my brother says big boobs make more fun. [m = motoric, s = sensorial/sensitive, b = both]
N. olfactorius (s)
N. opticus (s)
N. oculomotorius (m)
N. trochlearis (m)
N. trigeminus (b)
N. abducens (m)
N. facialis (b)
N. vestibulocochlearis (s)
N. glossopharyngeus (b)
N. vagus (b)
N. accessorius (m)
N. hypoglossus (m)
(fun)
clearance = (urine concentration x urine volume passed over time) / plasma concentration
the only useful thing my prof ever taught me for the renal physiology portion of my physiology course is that clearance is calculated by the equation “pissing under the sun” ( C = UV/P)